Assessing the Phytochemical Profile and Potential of Traditional Herbal Infusions against Aldose Reductase through In Silico Studies and LC-MS/MS Analysis

In the current market, there is a growing interest in traditional herbal nutraceuticals. Therefore, formulations have re-emerged as products with sought-after nutraceutical and disease-preventing properties. The health-promoting effects of bioactives are attributed to active phytoconstituents these plants. Thus, aim present study was evaluate putative effectiveness preparations ten herbs (chamomile, purple coneflower, lemon verbena, pennyroyal, spearmint, oregano, marjoram, headed savory, sea buckthorn, St. John’s wort) by combining silico techniques LC-MS/MS analysis. binding potential selected phenolic compounds, according literature web databases, investigated using molecular target prediction tools. Aldose reductase (AR), an enzyme polyol pathway which related hyperglycemic-induced pathologies, emerged most promising target. docking results showed that rosmarinic acid, caftaric naringenin, quercetin presented highest affinity. further step, phytochemical profile examined infusions, obtained analysis, revealed abovementioned compounds were present, mainly Lamiaceae family, designating savory infusion possible significant inhibitory activity against AR.